| Name | Party | Date |
| Thomas W. Watkins | 1851-54 | |
| George H. Yeaman | Democrat | 1854-58 |
| Albert G. Botts | Whig/Union | 1858-66 |
| George W. Triplett | State’s Rights | 1866-78 |
| Henry W. Scott | Democrat | 1878-83 |
| John D. Atchison | Democrat | 1883-90 |
| Jasper B. Karn | 1890-98 | |
| Edwin P. Taylor | 1898-1902 | |
| Horace M. Haskins | 1902-04 | |
| George V. Triplett | 1904-06 | |
| William W. Owen | 1906-14 | |
| Robert L. Lancaster | 1914-18 | |
| Clarence W. Wells | Republican | 1918-22 |
| Roy L. McFarland | Democrat | 1922-30 |
| James R. Wilson | Democrat | 1930-42 |
| Joseph E. Long | Democrat | 1942-49 |
| Richard B. Thompson | Democrat | 1949-54 |
| Norris B. Vincent | Democrat | 1954-58 |
| Thomas B. Birkhead | Democrat | 1958-66 |
| T. Patrick Tanner | Democrat | 1966-78 |
| William J. Froelich | Democrat | 1978-90 |
| Wilbur M. Norris | Republican | 1990-99 |
| L. Reid Haire | Democrat | 1999-2011 |
| Al Mattingly, Jr. | Republican | 2011- |